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International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

机译:国际基础和临床药理学联盟。第六十六届哺乳动物TRP离子通道家族的最新进展

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摘要

Transient receptor potential (TRP) channels are a large family of ion channel proteins, surpassed in number in mammals only by voltage-gated potassium channels. TRP channels are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. They respond to environmental stimuli such as temperature, pH, osmolarity, pheromones, taste, and plant compounds, and intracellular stimuli such as Ca2+ and phosphatidylinositol signal transduction pathways. However, it is still largely unknown how TRP channels are activated in vivo. Despite the uncertainties, emerging evidence using TRP channel knockout mice indicates that these channels have broad function in physiology. Here we review the recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels.
机译:瞬态受体电位(TRP)通道是离子通道蛋白的一大家族,在哺乳动物中仅通过电压门控钾通道得以超越。 TRP通道通过多种机制激活和调节,使其成为细胞传感器的合适候选者。它们对环境刺激(例如温度,pH,摩尔渗透压浓度,信息素,味道和植物化合物)以及细胞内刺激(例如Ca2 +和磷脂酰肌醇信号传导途径)产生响应。然而,在体内如何激活TRP通道仍然是很大程度上未知的。尽管存在不确定性,使用TRP通道敲除小鼠的新证据表明这些通道在生理学中具有广泛的功能。在这里,我们回顾哺乳动物TRP通道的生理,药理和病理生理功能的最新进展。

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